At least 12 people were reported killed Tuesday night in clashes in a Muslim majority Uighur region in western China.
China on Wednesday accused terrorists in a Muslim?Uighur?region of attacking civilians, but an exiled?Uighur?group said the violence that killed at least 12 people mainly targeted armed Chinese personnel.
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The bloodshed late Tuesday in the restive northwestern region of Xinjiang came at a sensitive time, ahead of next week's opening of China's national legislature, when authorities tighten security nationwide to prevent anything that would mar the annual session.
Officials and state media said the bloodshed started when assailants attacked civilians with knives on a commercial street in Yecheng city, killing 10 people; police fatally shot two of the attackers, the official accounts said.
Chinese Foreign Ministry spokesman Hong Lei called the attackers "terrorists" and said they attacked innocent civilians, "cruelly killing several of them in an appalling manner."
However, Dilxat Raxit, a spokesman for the German-based World Uyghur Congress, said that the violence in Yecheng ? called Kargilik by?Uighurs?? erupted because local residents "could no longer bear China's systematic repression," and have been denied outlets for peaceful protest.
He said local?Uighurs?told him seven armed Chinese security personnel were killed and that three people were shot to death. He said two more people were killed but did not provide any detail of those deaths. He said 10 people were injured, including two seriously hurt, and that police have detained 84 people. Police have sealed off the area, he said.
The government has failed to win over?Uighurs?and other ethnic minorities through policies to boost economic growth and incomes as it increases police presence and controls religious practices to deter displays of separatism. China's ethnic Tibetan regions have also been unsettled in recent months by scattered demonstrations and clashes with authorities, as well as self-immolations in protest against the government's policies.
"At present, Xinjiang is on the path of a leap-forward development," Hong, the Foreign Ministry spokesman, told reporters in Beijing. "We firmly oppose a handful of terrorists and separatists in sabotaging the peaceful development, good order, and unity.
A Communist Party official in Yecheng county, who declined to give his name, said that aside from the two assailants shot on the spot, all the remaining attackers were later captured by police. He refused to answer further questions. Calls to police offices in Yecheng went unanswered.
Censors blocked postings about the attack on microblogs. Searches on Sina Corporation's popular Weibo service returned the message: "In accordance with relevant laws, regulations and policies, 'Xinjiang Yecheng' search results were not shown."
Sporadic attacks occur in Xinjiang ? a region of oil and gas deposits, vast deserts, and towering mountains that abuts Central Asia ? despite a smothering security presence imposed following 2009 riots in the regional capital of Urumqi in which almost 200 people died. The riots pitted?Uighurs?against migrants from China's majority Han.
Much of the violence has been centered in Yecheng and other oasis cities in southern Xinjiang, a heartland of Uighur?culture. A group of?Uighurs?stormed a police station in the city of Hotan to the east of Yecheng on July 18 and took hostages, killing four. On July 30 and 31,?Uighurs?in Kashgar to the west hijacked a truck, set a restaurant on fire and stabbed people in the street. Authorities said 14 of the attackers were shot by police in Hotan, and five assailants were killed in the violence in Kashgar.
China says those events were organized terror attacks, but overseas?Uighur?groups say they were anti-government riots carried out by angry citizens.?Uighur?(pronounced WEE'-gur) activists and security analysts blame the violence on economic marginalization and restrictions on?Uighur?culture and the Muslim religion that are breeding frustration and anger among young?Uighurs.
Chinese authorities have offered little evidence to back up their claims of outside involvement and rarely provide details on arrests or punishment of the suspects. Tight information controls and the remoteness of the area, more than 2,175 miles (3,500 kilometers) west of Beijing, ensure that the circumstances surrounding such incidents often remain murky.
The government has periodically closed unregistered Islamic schools and study sessions, seeing them as a wellspring for radical separatism. The World Uyghur Congress has said that authorities in Xinjiang's Aksu region in recent weeks confiscated hundreds of tracts and videos and detained more than 100 people.
??You are here: DIME Home > Branding > NFL Football Logo History of the Legendary and Prominent NFL Shield
The well-known and renowned NFL football logo has certainly made a name for itself in the sports world. The crest is not just a representation of the teams but also a symbol for victory, glory, aggression, loyalty and celebration.
Author: Tammy Becker Date: Feb 28, 2012 - 1:06:03 AM
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The well-known and renowned NFL shield has certainly made a name for itself in the sports world. The crest is not just a representation of the team but also a symbol for victory, glory, aggression, loyalty and celebration.
It is a symbol that has united football fans from all over the country and has brought them down to one stadium. When it was formed in 1920, it started off with only eleven teams but now it is managing more than thirty two teams from all over America.
History of the NFL Football Logo Design:
The Old Symbol:
This symbol was created in 1940, two decades after the founding of NFL and has represented the football federation till 2008. It consists of a crest with 25 stars and an image of a football in the upper half of the image. The football in the image has often been nicknamed as the NFL hamburger due to its resemblance to the famous American snack. The bottom half of the design caters the team name initials. The crest is created with only three colors; red, dark blue and white which makes the image sophisticated and eye catching. These colors are also found in the national flag which gives the design a patriotic touch. The stars in the emblem are also illustrated for the same reasons; besides adding a hint of glamour to the design. The text has been scripted in thick and straight fonts with the letter L curved at the end that adds an artistic touch to the monogram.
The New Symbol:
In 2008, NFL created a leaner, meaner and darker version of their old emblem. In the new monogram, the crest was created to be slightly thinner and taller which the shade of blue going darker. The subtle changes in the emblem were made so that famous NFL would be able to update itself according to time but would not lose the traditional and historic touch that the corporation feels pride over. The stars in the image have also decreased to 8 from 25 to represent the 8 divisions that NFL caters to. The image of the football in the design is also made to look more 3 dimensional which no longer resemble a hamburger. While the colors and the basic shape remains the same, the text has lost its previous curviness and has been replaced with a sharp edged text that depicts professionalism and aggression.
This symbol has been an inspiration to many American football teams like the NY Giants logo, Minnesota Vikings football logo and the Houston Texas logo.
In conclusion, NFL has created a brand mark that contains all the important elements that any national emblem should have; it is a symbol of history, tradition, patriotism and pride that any American footballs fan would be proud to wear.
Tammy becker is a professional designer in logo design consultant. Writing on All car logos blog is another activity of her that she enjoys the most.
View all articles by Tammy Becker
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The ?new baby? episode has been a long-standing tradition for many T.V. shows.? However, current shows like Justified, Mad Men, Breaking Bad, and more are handling pregnancy and fatherhood in new ways.
The third season of the acclaimed series Justified now shares a common link with decades of television that came before it, it will have a ?new baby? episode.? The on-screen pregnancy began over five decades ago when Lucille Ball?s real-life pregnancy was capitalized upon in the series I Love Lucy.? Ratings soared, and in the 1953 episode ?Lucy Goes to the Hospital? was viewed by 44 million Americans.? In comparison, the presidential inauguration of Dwight Eisenhower, which aired the following day, only drew 29 million viewers.? While the ?new baby? episode is a significantly less novel concept than it was a few decades ago it can still be a draw for viewers, like when The Office beat out Grey?s Anatomy when Jim and Pam had a baby.
But an interesting, divergent trend has emerged in recent TV dramas: a subdued, sometimes all-but-unremarked-upon approach to the birth of a child. AMC?s Mad Men and Breaking Bad have each seen their lead protagonists grappling with new fatherhood?going through the full arc of the experience, from pregnancy to birth?but in a way that hasn?t significantly alter the either show?s overarching narrative.
Justified has more in common with Mad Men and Breaking Bad than its general approach to the ?new baby? plot device. Each of the show?s pregnancies was unplanned, and all three babies are potential casualties of the fundamentally unstable unions that created them. What we?re seeing is a new approach to what a new baby means on television. These babies aren?t characters unto themselves; they?re plot devices, which threaten to draw our leading men away from their respective callings (the law, advertising, and methamphetamine, for those keeping track at home). There?s a reason that ?new baby? episodes tend to feature more heavily in sitcoms; where babies offer a host of new opportunities for jokes in comedies, they rarely offer more than obstacles to be overcome in dramas.
Other drama-oriented shows which have, or are currently featuring a new baby/new father device include Dexter and The Walking Dead.
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AP - Former President Nelson Mandela was released from the hospital Sunday after an overnight stay for minor diagnostic surgery to determine the cause of an abdominal complaint, a spokesman for the country's current leader said.
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[unable to retrieve full-text content]AP - Gap Inc. reported a 40 percent drop in fourth-quarter profit as the clothing retailer wrestled with higher costs and had to discount heavily to attract shoppers during the crucial holiday season.
Heading house is a new nerve-racking time frame for the complete virginia relocation, and often it can be this dogs who are the foremost. Pet cats are specially liable to the worry from relocating home, along with regularly spouse and children pets or animals not to mention like to be called for; this misunderstanding for switching place can be quite upsetting for him or her.
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Online games and interactive maps could help pygmy tribes in Africa fight logging and poaching in their area.
Part of the Extreme Citizen Science (ExCiteS) programme, launched on Friday at University College London, UK, the work builds on research from anthropologist Jerome Lewis into data collection in extreme environments. Lewis has been working with indigenous people in the Republic of Congo and Cameroon since 2005 to develop tools for use by non-literate people.
In 2009, Lewis developed an icon-based interface, in collaboration with hardware provider Helveta, that could intuitively be used by the tribes affected by logging and poaching in their forest home. Once familiar with the hand-held device, the hunter-gatherers could use it to geotag trees crucial to their way of life - for example, those trees from which they harvest a particularly delicious, and commodifiable, type of caterpillar. The information was then fed back to logging companies and policy holders to try and save crucial areas of forest.
Now Lewis is moving one step further, making use of developments in tablets and smartphones to enable forest communities to gather multimedia data and feed it into intelligent maps. The data can be displayed on the maps so that users can see how the forest has changed over time.
"As climate change starts to affect the rising and falling of water in the forest, animals become difficult to find and as is the predictability of the arrival of fruits and insects. This has been dramatically affected by climate change," says Lewis.?
"Mapping changes over time will allow the forest people to start to notice the regularities that might emerge as things change. In theory you can start to adapt your behaviour to take account of that".
But one obstacle lies in the way - map illiteracy in the indigenous communities. To address this, Lewis is now collaborating with researchers from the ISI foundation in Italy, who have developed a platform for social games and experiments, Experimental Tribes, to teach the indigenous tribes how to read and interact with the maps they have been creating over the last few years.
Playing Blindate, a collaborative game that requires map-reading in order for two players to meet up, will encourage the tribe members to become familiar with locating themselves and places of interest on forest maps, says the project's Vittorio Loreto of Rome's Sapienza University in Italy.?
AP - The Interior Ministry on Wednesday said seven people were killed in clashes between Afghan security forces and protesters demonstrating against the burning of Muslim holy books at a NATO military base.
While Rick Santorum is busy spending his time on social issues, Mitt Romney has regained some ground in Michigan by concentrating on the economy, with CNBC contributor Robert Costa; Kevin Madden, Republican strategist; James Freeman, Wall Street Journa...
Being in business for yourself brings with it a certain level of anxiety. This is natural since you do not have any safety net. While striking out on your own brings with it a certain level of flexibility, you can increase your odds of success with these 10 secrets of alternative marketing.
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1. Unique/Risk Taking (with Measurement)
Perhaps the most basic step to success is to be unique. As Robert J. Ringer stated in his book Looking Out For # 1 if you?re not being different you?re just another thousandtlpulet. And if you that, what are you offering that they (your prospects) cannot get from 999 others? A unique offerings differentiates you from your competition.
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And certainly your life is going to be a bit like Thomas Edison?s. You?re going to have to face a number of failures before you see the shiny light of success. Find and record a metric to measure your failures.
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2. Blogging
Writing in your area of expertise (blogging) is a fact of life for contributing to your success. Frankly, there is no getting around it. If you don?t feel you are a good writer hire the project out. Failure to blog will have the natural consequence of your search engine results hovering above one click above nonexistent. Unless you are richer beyond the dreams of Alvarez, among the 10 secrets of alternative marketing, this should be your golden rule.
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3. Fiverr
The website fiverr.com is getting popular and for a darn good reason. Here you get to market your product or service for free, and if someone bites, you actually make a few dollars. While some people have turned fiverr.com into a fulltime living, most use it as a source for new leads. It completely turns around the traditional model of marketing. You get out there for free, and it paid a little bit to show off your stuff.
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4. News Agency Writing
Admittedly, this one is a little tougher to get into. While a good news agency performing in your market segment will probably accept your writing, it?s going to have to be better than your average blog. The upside is you are more quickly and knowledge to as an expert since you were found in a news agency. This is a great advantage because a news agency is considered an authority site which Carries great weight to the search engines. Additionally, news agencies get the highest priority in the time to indexing.
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5. Mobile Web
In mid February 2012 Cisco has announced its prediction that mobile web traffic will increase an eightfold in the next four years. Some people feel this is a conservative estimate. With tablet computers and smart phones entering the sub $200 range (Amazon Kindle) and some smart phones now in the sub $100 range along with the proliferation of wifi, the eightfold increase may get that mattered in less than four years, in some countries.
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While it may be a bit expensive, today to create a web site that is interactive to desktop and mobile devices, creating a separate web site with a single page dedicated to mobile devices with a focus on hyper local search feeds well into the desires for the search engines.
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6. Linked-in
The website Linkedin.com is the business equivalent of Facebook.Com. Today, it is the digital equivalent of going to an important social party where you are to see and be seen. A a novice mistake is to jump in with a buy from me message. It is considered as crass as jumping into a social party and selling yourself without getting to know the people around you.
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Get invited to groups, introduce your name and ask other people about what and how they?re doing. The favor will be returned with social etiquette.
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7. Thank You cards
In our 10 secrets of alternative marketing, this is a golden oldie and quite powerful as it sits forgotten. A handwritten thank you card, done with a fountain pen and mailed in the postal system. A common mistake in utilizing this special trick is to thank only after a sale. You will get many more conversions if you send this special card to a prospect who has done an inquiry.
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8. Groupon Style
For a time, the deep discount marketing model was all the rage. There are early indicators that it is beginning to burn out. Customers are beginning to become trained to only accept the discounts in certain situations. An example would be the movie theaters. While it might be a great way to fill seats, customers are learning that they can get movie tickets at half price if they?re willing to wait.
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The trick for a new business is to weigh the deep discounts against being discovered.
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9. Affilate Marketing
There are a number of web sites that pay the bills placing ads for products and services that resonate a chord with their readers. If you choose to go with affiliate marketing ensure that you pay your affiliates promptly. In this day of the inter webs word gets around quickly, one way or another.
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10. Newsletters
The subtle difference in our 10th secret of alternative marketing, newsletters vs. blogging is to announce in support the existence of your new business in community newsletters and newspapers. When you have success, remember tip number seven.
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Short URL: http://www.trcbnews.com/?p=7815
Posted by Jeffry Rocha on Feb 20 2012. Filed under Business. You can follow any responses to this entry through the RSS 2.0. You can leave a response or trackback to this entry
When running a affair that involves various forms of transportation as the main means of delivering services and commodities, effectual management of all these vehicles can prove to be one of the chief stumbling blocks in the whole operation.
Staying on top of all these vehicles? activities is certainly not a walk in the park, rather it is a wearisome process that freight and courier companies are all too used to.
Thankfully, there are those who have built a affair on providing various hardware and software programs for situations like these, and they are appropriately referred to as fleet management services. They provide a reliable means of tracking and observing any number of vehicles from anywhere in the world, with information that come in real-time updates.
Fleet management companies harness the power of a high alacrity global positioning system or GPS, to provide their clients with a continuous feed of vehicle tracking data. And the best in their field use only the latest equipment and fastest Internet relations to assure that their clients can access all the information they require, in an instant.
The entire process of vehicle tracking is accomplished by installing a GPS tracking device on the vehicle and linking it to a suitable GPS satellite. Once the system is online and the connection is established, the car navigation system will automatically be assessed for the vehicle?s exact location, the specific course it headed for, and its average alacrity. All the data are then sent to the company server where clients can request for updates by means of a desktop, portable computer, and mobile buzz.
Businesses can make use of the data gained from this vehicle tracking equipment to troubleshoot transport and delivery service problems, and do evidence based actions that can improve the efficiency of the whole operation.
Apart from delivery service companies, private individuals can also benefit from this technology when it comes to caring their cars and family members. The vehicle tracking package often comes with features like Geo fencing functions, remote vehicle immobilisation, speeding warnings, and a whole range of other features that car owners will find extremely helpful.
Fleet Management Software
Fleet Management Software And Hardware
Convenient Fleet Management Resources
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Contact: Greg Lester glester@wistar.org 215-898-3943 The Wistar Institute
First model of aggressive ovarian cancer demonstrates immune system's active role in tumor progression
Aggressive ovarian tumors begin as malignant cells kept in check by the immune system until, suddenly and unpredictably, they explode into metastatic cancer. New findings from scientists at The Wistar Institute demonstrate that ovarian tumors don't necessarily break "free" of the immune system, rather dendritic cells of the immune system seem to actively support the tumor's escape. The researchers show that it might be possible to restore the immune system by targeting a patient's own dendritic cells.
"Our model shows where the cancer is kept in check for relatively long periods, but once they become noticeable, tumors grow exponentially," said Jos R. Conejo-Garcia, M.D., Ph.D., an associate professor at Wistar and leader of the Tumor Microenvironment and Metastasis Program of Wistar's Cancer Center. "More importantly, we show that by depleting these dendritic cells of the immune system, we can reverse the effect, once again allowing our immune system to recognize the ovarian tumors."
Their findings, presented in the March issue of the Journal of Experimental Medicine, available online now, represent the first successful attempt to model the tumor microenvironment of human ovarian cancer in a mouse model of the disease. In essence, the model replicates the inflammatory surroundings that ovarian tumors experience in humans. The more accurate model provides a better tool for researchers to understand, prevent, and treat tumors.
"Our system uses oncogene-driven tumors that are spontaneously antigenic, thus avoiding the use of artificial foreign antigens that do not accurately replicate what drives anti-tumor immune responses in humans," Conejo-Garcia said.
Ovarian cancer remains one of the most deadly forms of cancer in women. According to the National Cancer Institute, 21,990 women will be diagnosed with ovarian cancer, and 15,460 women will die of the disease this year Because early-stage ovarian cancer does not often exhibit noticeable symptoms, many women are not diagnosed until the cancer is at a later stage, when it is most difficult to treat.
"While we have seen an increase in survival rates for most cancers over the last 40 years, ovarian cancer survival has only improved slightly since the 1970's," Conejo-Garcia said. "We created our ovarian cancer model to get a better understanding of how these tumors acquire such aggressive characteristics and evade the immune system."
According to Conejo-Garcia, their model demonstrates how a localized ovarian tumor flares into an aggressive metastatic disease.
"You can see where, if one ovary is cancerous, it is almost unrecognizable until an instantaneous moment, when it explodes into exponential growth," Conejo-Garcia said. "The key to this moment, our evidence suggests, is in the phenotypic changes taking place in the dendritic cells that are part of the tumor microenvironment."
In healthy tissue, dendritic cells function as sort of alarm system to alert the adaptive part of the immune system to potential threats. They work as antigen-presenting cells, offering foreign or disease-causing molecules (called antigen) to the white blood cells that can then respond to an infection or, in this case, tumorous growths. Amid the ovarian cancer microenvironment, dendritic cells also induce the immune system to attack tumor cells and inhibit their growth.
Until, that is, dendritic cells seem to switch sides.
"We see a change in the dendritic cells themselves, which allows tumors to progress to terminal disease in a very short time," Conejo-Garcia said. "Interestingly, the tumors themselves are still immunogenicthey could still otherwise elicit an immune responseit is just that the dendritic cells are actively suppressing the involvement of other anti-tumor immune cells; primarily T cells."
Conejo-Garcia and his colleagues believe that their findings offer a twist on the emerging theory of "cancer immunoeditting." The immunoeditting hypothesis suggests that the immune system actively "edits" tumor cells to eliminate antigens that are recognized by immune cells, keeping the cancer at bay before it becomes symptomatic. All symptomatic tumors, therefore, represent a failure of the immune system, where tumors lose their immunogenicitytheir ability to trigger and be recognized by our immune system.
The researchers found that that depleting dendritic cells early on accelerating tumor expansion, while removing dendritic cells later on actually delayed the tumor's progression. According to Conejo-Garcia, their findings suggest it is a change in the immune system itself, specifically the dendritic cells, and not primarily any loss of immunogenicity on the part of the tumor.
"It is almost as if anti-tumor T cells become exhausted, they can no longer keep up the effort," Conejo-Garcia said. "Still, our findings suggest that the enduring activity of these T cells would allow us to control metastatic ovarian cancer by targeting the dendritic cells that actively prevent their anti-tumor functions."
In fact, Conejo-Garcia and his colleagues have already developed a strategy to reprogram traitorous dendritic cells. In a an upcoming edition of the journal Cancer Research, available online now, the researchers demonstrate how synthetic RNA molecules can be used to win back the allegiance of dendritic cells and restore their ability to stimulate tumor suppression.
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Funding for this research was provided through grants from the National Cancer Institute and the Department of Defense.
The lead author of the study is Uciane K. Scarlett, Ph.D., a staff scientist in the Conejo-Garcia laboratory. Wistar co-authors also include Melanie R. Rutkowski, Ph.D. and Ximena Escovar-Fadul. Co-authors from Darmouth Medical School include Adam M. Rauwerdink, Ph.D., Jennifer Fields, Jason Baird, Juan R. Cubillos-Ruiz, Ph.D. (currently at Harvard University), Ana C. Jacobs, Jorge L. Gonzalez, M.D., John Weaver, Ph.D., and Steven Fiering, Ph.D.
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Contact: Greg Lester glester@wistar.org 215-898-3943 The Wistar Institute
First model of aggressive ovarian cancer demonstrates immune system's active role in tumor progression
Aggressive ovarian tumors begin as malignant cells kept in check by the immune system until, suddenly and unpredictably, they explode into metastatic cancer. New findings from scientists at The Wistar Institute demonstrate that ovarian tumors don't necessarily break "free" of the immune system, rather dendritic cells of the immune system seem to actively support the tumor's escape. The researchers show that it might be possible to restore the immune system by targeting a patient's own dendritic cells.
"Our model shows where the cancer is kept in check for relatively long periods, but once they become noticeable, tumors grow exponentially," said Jos R. Conejo-Garcia, M.D., Ph.D., an associate professor at Wistar and leader of the Tumor Microenvironment and Metastasis Program of Wistar's Cancer Center. "More importantly, we show that by depleting these dendritic cells of the immune system, we can reverse the effect, once again allowing our immune system to recognize the ovarian tumors."
Their findings, presented in the March issue of the Journal of Experimental Medicine, available online now, represent the first successful attempt to model the tumor microenvironment of human ovarian cancer in a mouse model of the disease. In essence, the model replicates the inflammatory surroundings that ovarian tumors experience in humans. The more accurate model provides a better tool for researchers to understand, prevent, and treat tumors.
"Our system uses oncogene-driven tumors that are spontaneously antigenic, thus avoiding the use of artificial foreign antigens that do not accurately replicate what drives anti-tumor immune responses in humans," Conejo-Garcia said.
Ovarian cancer remains one of the most deadly forms of cancer in women. According to the National Cancer Institute, 21,990 women will be diagnosed with ovarian cancer, and 15,460 women will die of the disease this year Because early-stage ovarian cancer does not often exhibit noticeable symptoms, many women are not diagnosed until the cancer is at a later stage, when it is most difficult to treat.
"While we have seen an increase in survival rates for most cancers over the last 40 years, ovarian cancer survival has only improved slightly since the 1970's," Conejo-Garcia said. "We created our ovarian cancer model to get a better understanding of how these tumors acquire such aggressive characteristics and evade the immune system."
According to Conejo-Garcia, their model demonstrates how a localized ovarian tumor flares into an aggressive metastatic disease.
"You can see where, if one ovary is cancerous, it is almost unrecognizable until an instantaneous moment, when it explodes into exponential growth," Conejo-Garcia said. "The key to this moment, our evidence suggests, is in the phenotypic changes taking place in the dendritic cells that are part of the tumor microenvironment."
In healthy tissue, dendritic cells function as sort of alarm system to alert the adaptive part of the immune system to potential threats. They work as antigen-presenting cells, offering foreign or disease-causing molecules (called antigen) to the white blood cells that can then respond to an infection or, in this case, tumorous growths. Amid the ovarian cancer microenvironment, dendritic cells also induce the immune system to attack tumor cells and inhibit their growth.
Until, that is, dendritic cells seem to switch sides.
"We see a change in the dendritic cells themselves, which allows tumors to progress to terminal disease in a very short time," Conejo-Garcia said. "Interestingly, the tumors themselves are still immunogenicthey could still otherwise elicit an immune responseit is just that the dendritic cells are actively suppressing the involvement of other anti-tumor immune cells; primarily T cells."
Conejo-Garcia and his colleagues believe that their findings offer a twist on the emerging theory of "cancer immunoeditting." The immunoeditting hypothesis suggests that the immune system actively "edits" tumor cells to eliminate antigens that are recognized by immune cells, keeping the cancer at bay before it becomes symptomatic. All symptomatic tumors, therefore, represent a failure of the immune system, where tumors lose their immunogenicitytheir ability to trigger and be recognized by our immune system.
The researchers found that that depleting dendritic cells early on accelerating tumor expansion, while removing dendritic cells later on actually delayed the tumor's progression. According to Conejo-Garcia, their findings suggest it is a change in the immune system itself, specifically the dendritic cells, and not primarily any loss of immunogenicity on the part of the tumor.
"It is almost as if anti-tumor T cells become exhausted, they can no longer keep up the effort," Conejo-Garcia said. "Still, our findings suggest that the enduring activity of these T cells would allow us to control metastatic ovarian cancer by targeting the dendritic cells that actively prevent their anti-tumor functions."
In fact, Conejo-Garcia and his colleagues have already developed a strategy to reprogram traitorous dendritic cells. In a an upcoming edition of the journal Cancer Research, available online now, the researchers demonstrate how synthetic RNA molecules can be used to win back the allegiance of dendritic cells and restore their ability to stimulate tumor suppression.
###
Funding for this research was provided through grants from the National Cancer Institute and the Department of Defense.
The lead author of the study is Uciane K. Scarlett, Ph.D., a staff scientist in the Conejo-Garcia laboratory. Wistar co-authors also include Melanie R. Rutkowski, Ph.D. and Ximena Escovar-Fadul. Co-authors from Darmouth Medical School include Adam M. Rauwerdink, Ph.D., Jennifer Fields, Jason Baird, Juan R. Cubillos-Ruiz, Ph.D. (currently at Harvard University), Ana C. Jacobs, Jorge L. Gonzalez, M.D., John Weaver, Ph.D., and Steven Fiering, Ph.D.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
AP - After all the testimonials from relatives and friends, the songs from legends and pop stars, the preaching and even laughter, the raw emotion of Whitney Houston's funeral came down to just one moment: The sound of her own voice.
AP - A resurgent Rick Santorum hopes to spring his next big surprise in Michigan. Newt Gingrich looks for a campaign revival in the Bible Belt. Mitt Romney has his home state of Massachusetts, and the luxury of picking his spots elsewhere, if not everywhere, as the race for the Republican presidential nomination roars back to life.
These days, PPC search engine marketing has become an essential part of the marketing mix. per click is an effective internet marketing activity that helps budding as well as established companies to benefit from targeted traffic footprints. Especially, this form of marketing can be beneficial to businesses that have not yet gained sufficient search engine credibility to be listed in the organic section of major search providers. That?s the reason nowadays, almost all popular search engines like Google (AdWords), MSN (adCenter) are offering PPC services to their customers. Thus, with the growing popularity of PPC as an affordable and reliable technique, many PPC companies have started providing different PPC services including keyword selection and optimization, bid price management, campaign distribution specification and optimization, quality score management, regular competitor monitoring, regular customized reports and more.
Actually, pay per click search engine marketing allows you to be listed at the top of search results quickly, which helps you to quickly gather feedback on market conditions.
web marketing is where advertisers pay when a user clicks on an advertisement and visits their website. PPC web marketing is deployed extensively across search engines, advertising networks, content-based websites and blogs as part of a web marketing campaign. marketing and web marketing campaigns focus on keyword phrases relevant to their target market. Pay per click internet marketing offers focused and measurable deployment of search marketing. PPC offers flexible and measurable website marketing campaigns calculated to give you manageable control on your web marketing investments and returns.
PPC services are attractive and contain interactive advertisements. Individuals may be able to gain more information about products or services after clicking on that particular advertisement. In short, PPC services are a kind of search engine marketing technique in which advertisers pay depending on the number of clicks made on the published advertisements. In brief, by the system of PPC search engine internet marketing, a website can achieve better positions on recognized search engine pages conveniently and much faster. In the hand of experienced PPC professionals, a pay per click campaign can ensure quality traffic in the shortest span of time.
Mary Kantorowski of Fairfield, Conn. is seen at home in a Tuesday, Feb. 14, 2012 photo. Kantorowski, whose son served her with eviction papers on her 98th birthday two months ago, is fighting his efforts to remove her from her home. Her oldest son, 71-year-old Peter Kantorowski of Trumbull, says he's concerned about his her well-being. (AP Photo/Connecticut Post, Brian A. Pounds) MANDATORY CREDIT
Mary Kantorowski of Fairfield, Conn. is seen at home in a Tuesday, Feb. 14, 2012 photo. Kantorowski, whose son served her with eviction papers on her 98th birthday two months ago, is fighting his efforts to remove her from her home. Her oldest son, 71-year-old Peter Kantorowski of Trumbull, says he's concerned about his her well-being. (AP Photo/Connecticut Post, Brian A. Pounds) MANDATORY CREDIT
In a Feb. 14, 2012 photo, Jack Kantorowski, left of Fairfield, Ct., is photographed with his mother Mary, 98, at her home in Fairfield, Ct. Jack wants his mother Mary, 98, right, to stay in her home. But her older son Peter, served her with eviction papers on her 98th birthday, saying that he's concerned about her well-being. She is fighting the eviction effort. (AP Photo/Connecticut Post, Brian A. Pounds) MANDATORY CREDIT
NEW HAVEN, Conn. (AP) ? A 98-year-old Connecticut woman facing eviction by her son says she's upset and wants to stay in the home where she raised her children.
Mary Kantorowski has lived in her yellow Cape Cod-style home in Fairfield since 1953. She said Friday that the home means "everything" to her.
Her oldest son, 71-year-old Peter Kantorowski of Trumbull, told the Connecticut Post he's concerned about her well-being. He says when he last saw her eight months ago, she seemed disoriented and was living in poor conditions.
Peter Kantorowski owns the house. He says his mother has rejected his suggestions to live with him or in a nursing home.
Another son, Jack Kantorowski, tells WTNH-TV that his brother is a "scumbag."
??Rackspace Acquires SharePoint911 to Provide Industry Leading SharePoint Expertise (2012-02-17 02:32)
Rackspace takes Fanatical Support into the application layer with world-class SharePoint experts
??Allied Motion Announces Record Profit for the Quarter and Year Ended December 31, 2011 (2012-02-17 02:17)
Allied Motion Technologies Inc. (NASDAQ-NMS: AMOT) today announced it achieved record revenues and net income for the year ended December 31, 2011. Net income for the year was $6,967,000 or $.81 per diluted share compared to net income of $3,585,000 or $.45 per diluted share for 2010. The results this year include an adjustment to the contingent consideration that was originally recorded as part of the purchase price for the Ostergrens Elmotor AB acquisition that was completed on December 30, 2010. The adjustment had the effect of increasing both pretax and after tax profit by $1,101,000 resulting from the final determination of the contingent payment amount. Excluding this adjustment, net income for 2011 was a record $5,866,000 or $.68 per diluted share.
??Maxthon Mobile Adds 'Quick and Easy' Screenshot Capture to Easily Save, Send and Share Full Screengrabs and Pictures (2012-02-17 02:12)
SAN FRANCISCO, February 17, 2012 --
??Khronos Group Announces the KITE Initiative to Connect Industry to Education (2012-02-17 02:07)
The Khronos? Group, an industry consortium creating open standards for the acceleration of graphics, parallel computing, dynamic media and sensor processing, today announced the launch of the KITE? (Khronos Institute for Training and Education) Program. KITE is a community-based, cooperative effort between The Khronos Group organization, its individual members, and the worldwide educational community to encourage the wide availability of courses and a consistently high-level of quality in education regarding Khronos open standard APIs, such as OpenGL? ES. The KITE website is now available for educators and students to enroll and share courseware: http://www.khronos.org/kite/en/.
??TCL Became the Exclusive Partner of CCTV 3D Channel (2012-02-17 01:52)
Seizing opportunities in the growing 3D TV Market in the PRC continuing to increase the proportion of high-end products
??Maxthon Mobile Adds 'Quick and Easy' Screenshot Capture to Easily Save, Send and Share Full Screengrabs and Pictures (2012-02-17 01:22)
San Francisco, Feb. 16, 2012 "> Maxthon (www.maxthon.com), a global software and web services company, announces the release of a new screen grab utility for Maxthon Mobile. With this new plug-in, users can easily take snapshots of entire web pages, save them on their Android phones, or upload to social media sites like Facebook and Twitter. Users can download the latest version of Maxthon Mobile at http://www.maxthon.com/maxthon-mobile/
??Yippy, Inc. (YIPI) Expands Executive Team to Create Digital Marketing Group (2012-02-17 01:22)
FORT MYERS, Fla., Feb. 16, 2012 --?Yippy, Inc. (Pinksheets: YIPI) (www.yippy.com) ("Yippy" or the "Company"), providers of the world's fastest, family friendly search engine and web portal reported that it has hired Frank Paonessa as Chief Sales Officer ? Digital Marketing Group effective immediately.
??Westcon Group Announces Acquisition of PT Netpoleon (2012-02-17 01:12)
-- Transaction Builds on Distributor's Strong Global Footprint with Addition of a Significant Presence in Indonesia
??Juan Gonzalo Angel Pioneers Colombian Theme Channels For Mobile Phones (2012-02-17 00:32)
BOGOTA, Colombia, Feb. 16, 2012 -- Global Media Telecommunications, a company dedicated to the production of thematic signals for both cable and satellite systems in the Spanish-speaking market, will launch a channel specializing in 24 hour news for Latin America, the Caribbean and USA. Additional development of newscasts subtitled in English for the American market will be available as well. In addition to Theme Channels, advanced negotiations with telephone companies have begun create a presence through IPTV for the provision of breaking news to mobile devices.
??Tetra Tech to Present at the Baird Business Solutions Conference (2012-02-17 00:07)
Tetra Tech, Inc. (NASDAQ-NMS: TTEK) announced today that Mike Bieber, Senior Vice President of Corporate Development, will give a presentation to investors at the Baird Business Solutions Conference in Boston on Thursday, March 1, 2012, at 9:10 a.m. Eastern Time. Tetra Tech invites investors and other interested parties to attend a live webcast of its presentation. The webcast and a copy of the presentation slides will be available on the Company?s website at www.tetratech.com. A replay of the presentation will be available on the website following the presentation.
??Matthew Key, Head, Telef?nica Digital; Caroline Thomson, COO, BBC; Graeme Oxby, Managing Director, Virgin; Andrew Harrison, CEO, Best Buy Europe; Byun Jae-Woan, CTO, SK Telecom; David Lister, CIO, National Grid; Ed Richards, Chief Executive, Ofcom to Speak at Rutberg Summit: London (2012-02-17 00:02)
SAN FRANCISCO, February 16, 2012 --
??100% of Roman Catholic Bishops Have Now Publicly Denounced HHS Mandate (2012-02-17 00:02)
Health care mandate also opposed by 65% of lay Catholics
??Matthew Key, Head, Telefonica Digital; Caroline Thomson, COO, BBC; Graeme Oxby, Managing Director, Virgin; Andrew Harrison, CEO, Best Buy Europe; Byun Jae-Woan, CTO, SK Telecom; David Lister, CIO, National Grid; Ed Richards, Chief Executive, Ofcom to Speak at Rutberg Summit: London (2012-02-16 23:32)
SAN FRANCISCO, Feb. 16, 2012 --?Rutberg & Company today announced speakers for Rutberg Summit: London 2012, taking place April 23-25 at Claridge's in London, England.
??tw telecom to Present at Investor Conferences (2012-02-16 23:22)
LITTLETON, Colo., Feb. 16, 2012 --?tw telecom Inc. (NASDAQ-NMS: TWTC), a leading provider of managed services, including Business Ethernet, converged and IP VPN solutions for enterprises throughout the U.S. and globally, will present at the following conferences:
??Harley-Davidson Joins Forces With Marvel (2012-02-16 23:22)
MILWAUKEE, Feb. 16, 2012 --?Harley-Davidson and Marvel Entertainment have come together again for the Assemble Your Freedom contest where customers can assemble their dream bike and become a character in an Avengers comic.
??iRobot Changes Leadership in Government and Industrial Robots Division (2012-02-16 23:07)
iRobot Corp. (NASDAQ-NMS: IRBT), a leader in robotic technology-based solutions, today announced Robert (Knob) Moses is leaving iRobot to pursue other interests. Moses will remain with iRobot through a transition period.
??USCAR Helps to Develop Charging-Readiness Tools for Plug-in & Electric Vehicles Through U.S. DRIVE (2012-02-16 23:07)
As a member of the U.S. DRIVE Grid Interaction Tech Team (GITT), the U.S. Council for Automotive Research LLC (USCAR) recently played a key role in assisting the U.S. Department of Energy (DOE) to develop a model streamlining process for permitting and inspecting home-charging stations for plug-in hybrid electric and electric vehicles (PHEVs/EVs), as well as information tools for the actual installation process.
T-Mobile and HTC have a new sleek curvy smart phone in the market, the Mytouch. From time to time, HTC introduces new smart phones in market for billions of users, some users use their smart phone for short period and then they replace it but many users keep their mobiles for long-term usage. Therefore, this is very important to keep protection measures for better handling and protection purpose.
Due to its smooth body, it is very important to use Mytouch protection case for the safety purposes. Some smart phone users are very concerned about the safety of their phones but some do not even bother to place them in a safer place. Even its first precautionary measure for the safety of any smart phone but they do ignore it.
Smart phone users think that the accessories which come with the phone is worth protection and they do protect their hands free, charger, but they do not much care about the protection case. To some it is an added burden not an asset since they hate removing the phone out of the case. There are so many myTouch accessories are available to help make your mobile experience that much more memorable.
The myTouch case will keep your phone safe from the damages, for example, you have table in office on which you place daily usage accessories. For instance, you have 2 shelves and you put a phone with a case on one. After some time your concentration gets distracted and you put stapler and other stuff there. Without the screen protector chances are the display gets damaged or any other issue may arise. The issue of portability is a breeze if you have a case, as when travelling you buckle it or hand it on the neck just to keep you from leaving it behind in the vehicle or train.
There is another advantage of protection cases. Having the phone in the case protects it from heat and other adverse weather. If you do not put in protection case and rain just starts, then it is possible that your phone may start malfunctioning with its touch function or even die. There is that change in the overall looks of the phone when you have in a protection case. Let us say, if you have very stylish and beautiful case, then everyone will notice it. Your Mytouch smart phone becomes more of a celebrity gadget.
If you have beautiful protection case, smooth myTouch screen protector, and different accessories, you can claim that you are perfect mobile phone user. The figure of the case is in such a way that is does not hinder any other access to the phone. Design is the key factor that takes up choice, and you can also add to it the material used in making the case.
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Public release date: 20-Feb-2012
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